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Sacroiliac fusion is an accepted surgical treatment for several types of lumbar spinal disorders. It has been attempted with a variety of methods, including screws and wires. The authors report a modification of the poly-L-lactic acid method for sacroiliac fusion. To evaluate the feasibility of sacroiliac fusion using a novel poly-L-lactic acid plate in a cadaver model. Poly-L-lactic acid is a bioresorbable plate. It was applied to the sacroiliac joint in 9 fresh lumbar spines of 6 cadavers after vertebrectomy and discectomy. Plain radiographs were taken to evaluate fusion status and the sagittal plane motion of the sacroiliac joint. The strength of the sacroiliac joint was tested. Spinal tissues were examined histologically. Plates were easily applied to the sacroiliac joint without any problems. At 2 weeks, all cadavers showed evidence of bone union. The mean strength of the sacroiliac joint after fusion was 23.7 N, ranging from 17.9 to 28.9 N. There was no evidence of any loosening of the plates or fractures of the union. On histologic examination, ossification was not observed in the sacroiliac joint, but bone formation was found in the endplates of the adjacent vertebrae in some specimens. Complete sacroiliac fusion using the poly-L-lactic acid plate was achieved in all cadavers within 2 weeks, although there was partial ossification in the endplates of the adjacent vertebrae.Effect of three-dimensional electrospun scaffolds on rat mesenchymal stem cells.
Mesenchymal stem cells (MSCs) have many potentials in regenerative medicine. For a successful tissue engineering, bone tissue engineering based on the interactions between scaffolds and cells is a useful way. In this study
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